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1169: 75 Residue Monomer Design

Closed since over 10 years ago

Intermediate Overall Design

Summary

Created
December 11, 2015
Expires
Max points
100
Description

This is a basic 75 residue design puzzle without any Fragment Filter. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Italiani Al Lavoro 11. Italiani Al Lavoro 3 pts. 9,877
  2. Avatar for BOINC@Poland 12. BOINC@Poland 2 pts. 9,486
  3. Avatar for Freedom Folders 13. Freedom Folders 1 pt. 9,042
  4. Avatar for freefolder 14. freefolder 1 pt. 8,442
  5. Avatar for Deleted group 15. Deleted group pts. 7,879
  6. Avatar for CureCoin 16. CureCoin 1 pt. 7,213
  7. Avatar for NYIT OW BIOL-340 Fall 2015 17. NYIT OW BIOL-340 Fall 2015 1 pt. 7,184
  8. Avatar for SHELL 18. SHELL 1 pt. 2,866
  9. Avatar for Team South Africa 19. Team South Africa 1 pt. 0
  10. Avatar for Natural Abilities 20. Natural Abilities 1 pt. 0
  1. Avatar for TD06 141. TD06 Lv 1 1 pt. 7,595
  2. Avatar for wojak902 142. wojak902 Lv 1 1 pt. 7,580
  3. Avatar for pandapharmd 143. pandapharmd Lv 1 1 pt. 7,542
  4. Avatar for johncich 144. johncich Lv 1 1 pt. 7,499
  5. Avatar for jebbiek 145. jebbiek Lv 1 1 pt. 7,407
  6. Avatar for cnhrcolemam 146. cnhrcolemam Lv 1 1 pt. 7,405
  7. Avatar for emdee314 147. emdee314 Lv 1 1 pt. 7,387
  8. Avatar for DScott 148. DScott Lv 1 1 pt. 7,366
  9. Avatar for gruener-zwer 149. gruener-zwer Lv 1 1 pt. 7,357
  10. Avatar for mb96 150. mb96 Lv 1 1 pt. 7,242

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.