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1171: 60 Residue Symmetric Dimer Design: H-Bond Networks

Closed since about 10 years ago

Intermediate Overall Design Symmetry

Summary

Created
December 17, 2015
Expires
Max points
100
Description

In this puzzle, the bonus for Hbond networks has been increased, but only Hbond networks that are at least 75% satisfied will be rewarded. Furthermore, no more than three inter-molecular Hbonds may contribute to the filter! There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds, with 1-4 hydrogen bonds spanning the dimer interface. In addition, at least 75% of all polar atoms in the network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 18 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 48 residues are buried in the core of the entire complex (including the interface between monomer units).

smilingone Lv 1

bkoep… it seems that most can't access this puzzle in client. Does it require an old client to play it?

alwen Lv 1

Not only does this puzzle not show in my Puzzle Menu, it also does not show up in the "Social" tab.

Usually, in the Social tab, all puzzles show up, even before they are released, but 1171 doesn't.

brgreening Lv 1

I am running Windows 10. I am using devprev (see below)
C:\FolditLogs>ver

Microsoft Windows [Version 10.0.10240]

buildid: 20151215-9e58b22c38-win_x86-devprev

I see no option to download my error file as in the feedback
section.

Here is a segment of my error file when I attempted to download
puzzle 1171.

Notice : This nickname is registered and protected. If it is your Notice : nick, type /msg NickServ IDENTIFY password. Otherwise, Notice : please choose a different nick. Notice : Password accepted - you are now recognized. IDENTIFIED Private message : message t1450429795.7658 b48b737ceaeb0d71ccb3d4634478f59e puzzle 2001672 download puzzle: 2001672 exiting... Option file found. Sending... closing boinc... Sending SOPs:

done.
IRC::run error, code = 5, desc = Remote connection closed
Exiting IRC::run