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1172: 85 Residue Monomer Design

Closed since over 10 years ago

Intermediate Overall Design

Summary

Created
December 18, 2015
Expires
Max points
100
Description

This is a basic 85 residue design puzzle without any Fragment Filter. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Team South Africa 11. Team South Africa 1 pt. 9,105
  2. Avatar for BOINC@Poland 12. BOINC@Poland 1 pt. 9,061
  3. Avatar for Natural Abilities 13. Natural Abilities 1 pt. 9,021
  4. Avatar for CureCoin 14. CureCoin 1 pt. 6,898
  5. Avatar for DSN @ Home 15. DSN @ Home 1 pt. 0
  1. Avatar for Mouq 121. Mouq Lv 1 2 pts. 8,626
  2. Avatar for JackONeill12 122. JackONeill12 Lv 1 2 pts. 8,609
  3. Avatar for Swiper 123. Swiper Lv 1 2 pts. 8,572
  4. Avatar for harvardman 124. harvardman Lv 1 2 pts. 8,552
  5. Avatar for Alistair69 125. Alistair69 Lv 1 2 pts. 8,541
  6. Avatar for Cerzax 126. Cerzax Lv 1 2 pts. 8,449
  7. Avatar for ViJay7019 127. ViJay7019 Lv 1 1 pt. 8,385
  8. Avatar for martinf 128. martinf Lv 1 1 pt. 8,380
  9. Avatar for guineapig 129. guineapig Lv 1 1 pt. 8,370
  10. Avatar for johngran 130. johngran Lv 1 1 pt. 8,363

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.