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1172: 85 Residue Monomer Design

Closed since over 10 years ago

Intermediate Overall Design

Summary

Created
December 18, 2015
Expires
Max points
100
Description

This is a basic 85 residue design puzzle without any Fragment Filter. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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  3. Avatar for Natural Abilities 13. Natural Abilities 1 pt. 9,021
  4. Avatar for CureCoin 14. CureCoin 1 pt. 6,898
  5. Avatar for DSN @ Home 15. DSN @ Home 1 pt. 0
  1. Avatar for pvc78 41. pvc78 Lv 1 35 pts. 10,373
  2. Avatar for gitwut 42. gitwut Lv 1 34 pts. 10,364
  3. Avatar for aznarog 43. aznarog Lv 1 33 pts. 10,363
  4. Avatar for KarenCH 44. KarenCH Lv 1 32 pts. 10,356
  5. Avatar for joremen 45. joremen Lv 1 31 pts. 10,336
  6. Avatar for g_b 46. g_b Lv 1 30 pts. 10,319
  7. Avatar for justjustin 47. justjustin Lv 1 29 pts. 10,273
  8. Avatar for Bautho 48. Bautho Lv 1 28 pts. 10,269
  9. Avatar for christioanchauvin 49. christioanchauvin Lv 1 28 pts. 10,258
  10. Avatar for isaksson 50. isaksson Lv 1 27 pts. 10,224

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.