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1172: 85 Residue Monomer Design

Closed since about 10 years ago

Intermediate Overall Design

Summary

Created
December 18, 2015
Expires
Max points
100
Description

This is a basic 85 residue design puzzle without any Fragment Filter. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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    1. Beta Folders
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  1. Avatar for phi16 21. phi16 Lv 1 2 pts. 10,652
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  5. Avatar for O Seki To 25. O Seki To Lv 1 1 pt. 10,615
  6. Avatar for 01010011111 26. 01010011111 Lv 1 1 pt. 10,614
  7. Avatar for bob1928 27. bob1928 Lv 1 1 pt. 10,595
  8. Avatar for bendbob 28. bendbob Lv 1 1 pt. 10,591
  9. Avatar for dbuske 29. dbuske Lv 1 1 pt. 10,590
  10. Avatar for ManVsYard 30. ManVsYard Lv 1 1 pt. 10,589

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.