Placeholder image of a protein
Icon representing a puzzle

1172: 85 Residue Monomer Design

Closed since about 10 years ago

Intermediate Overall Design

Summary

Created
December 18, 2015
Expires
Max points
100
Description

This is a basic 85 residue design puzzle without any Fragment Filter. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 10,860
  2. Avatar for Contenders 2. Contenders 70 pts. 10,786
  3. Avatar for Go Science 3. Go Science 47 pts. 10,726
  4. Avatar for Anthropic Dreams 4. Anthropic Dreams 30 pts. 10,691
  5. Avatar for Gargleblasters 5. Gargleblasters 19 pts. 10,666
  6. Avatar for Void Crushers 6. Void Crushers 11 pts. 10,625
  7. Avatar for HMT heritage 7. HMT heritage 7 pts. 10,615
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 4 pts. 10,533
  9. Avatar for Deleted group 9. Deleted group pts. 10,447
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 1 pt. 9,858
  1. Avatar for Timo van der Laan 11. Timo van der Laan Lv 1 79 pts. 10,625
  2. Avatar for Galaxie 12. Galaxie Lv 1 77 pts. 10,623
  3. Avatar for O Seki To 13. O Seki To Lv 1 75 pts. 10,604
  4. Avatar for reefyrob 14. reefyrob Lv 1 73 pts. 10,602
  5. Avatar for hpaege 15. hpaege Lv 1 71 pts. 10,591
  6. Avatar for spvincent 16. spvincent Lv 1 69 pts. 10,589
  7. Avatar for Blipperman 17. Blipperman Lv 1 68 pts. 10,579
  8. Avatar for pauldunn 18. pauldunn Lv 1 66 pts. 10,575
  9. Avatar for shettler 19. shettler Lv 1 64 pts. 10,566
  10. Avatar for stomjoh 20. stomjoh Lv 1 63 pts. 10,550

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.