Placeholder image of a protein
Icon representing a puzzle

1174: 70 Residue Symmetric Hexamer Design: Protein Snowflakes

Closed since about 10 years ago

Intermediate Overall Design Symmetry

Summary

Created
December 23, 2015
Expires
Max points
100
Description

This is a symmetric hexamer design puzzle with 70 residues; there will be six symmetric chains to manage. This puzzle includes the H-bond Network Filter, but requires that networks are at least 75% satisfied! See the puzzle comments for more details. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. This puzzle will remain open for two weeks.

BONUS: It's winter here in Seattle, but we still haven't seen any snow! Submit your best "protein snowflake" using the Upload for Scientists button and the Foldit team will post their favorite snowflakes on the blog! Check out previous Foldit protein snowflakes here!

Top groups

  1. Avatar for Natural Abilities 11. Natural Abilities 4 pts. 10,419
  2. Avatar for BOINC@Poland 12. BOINC@Poland 3 pts. 9,572
  3. Avatar for Team South Africa 13. Team South Africa 2 pts. 8,742
  4. Avatar for Nerdfighters 14. Nerdfighters 1 pt. 4,031
  5. Avatar for It's over 9000! 15. It's over 9000! 1 pt. 3,822
  6. Avatar for Eὕρηκα! Heureka! 16. Eὕρηκα! Heureka! 1 pt. 0
  7. Avatar for CureCoin 17. CureCoin 1 pt. 0
  8. Avatar for Deleted group 18. Deleted group pts. 0
  9. Avatar for SETI.Germany 19. SETI.Germany 1 pt. 0
  10. Avatar for Boinc.be 20. Boinc.be 1 pt. 0
  1. Avatar for Mark- 11. Mark- Lv 1 83 pts. 13,717
  2. Avatar for pauldunn 12. pauldunn Lv 1 81 pts. 13,643
  3. Avatar for hpaege 13. hpaege Lv 1 80 pts. 13,638
  4. Avatar for Galaxie 14. Galaxie Lv 1 78 pts. 13,614
  5. Avatar for viosca 15. viosca Lv 1 77 pts. 13,601
  6. Avatar for gmn 16. gmn Lv 1 75 pts. 13,587
  7. Avatar for Anfinsen_slept_here 17. Anfinsen_slept_here Lv 1 74 pts. 13,586
  8. Avatar for mirp 18. mirp Lv 1 72 pts. 13,584
  9. Avatar for jamiexq 19. jamiexq Lv 1 71 pts. 13,575
  10. Avatar for grogar7 20. grogar7 Lv 1 70 pts. 13,550

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds, with 1-12 hydrogen bonds spanning the dimer interface. In addition, at least 75% of all polar atoms in the network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 21 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 168 residues are buried in the core of the entire complex (including the interface between monomer units).