Placeholder image of a protein
Icon representing a puzzle

1174: 70 Residue Symmetric Hexamer Design: Protein Snowflakes

Closed since over 10 years ago

Intermediate Overall Design Symmetry

Summary

Created
December 23, 2015
Expires
Max points
100
Description

This is a symmetric hexamer design puzzle with 70 residues; there will be six symmetric chains to manage. This puzzle includes the H-bond Network Filter, but requires that networks are at least 75% satisfied! See the puzzle comments for more details. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. This puzzle will remain open for two weeks.

BONUS: It's winter here in Seattle, but we still haven't seen any snow! Submit your best "protein snowflake" using the Upload for Scientists button and the Foldit team will post their favorite snowflakes on the blog! Check out previous Foldit protein snowflakes here!

Top groups

  1. Avatar for CHS SGF,MO 21. CHS SGF,MO 1 pt. 0
  2. Avatar for DSN @ Home 22. DSN @ Home 1 pt. 0
  1. Avatar for kitek314_pl 101. kitek314_pl Lv 1 10 pts. 9,572
  2. Avatar for ecali 102. ecali Lv 1 10 pts. 9,468
  3. Avatar for SouperGenious 103. SouperGenious Lv 1 9 pts. 9,395
  4. Avatar for Mohambone 104. Mohambone Lv 1 9 pts. 9,201
  5. Avatar for HorribleIgor 105. HorribleIgor Lv 1 9 pts. 9,027
  6. Avatar for NotJim99 106. NotJim99 Lv 1 9 pts. 9,019
  7. Avatar for bhodg1 107. bhodg1 Lv 1 8 pts. 8,985
  8. Avatar for poiuyqwert 108. poiuyqwert Lv 1 8 pts. 8,955
  9. Avatar for fiendish_ghoul 109. fiendish_ghoul Lv 1 8 pts. 8,766
  10. Avatar for doctaven 110. doctaven Lv 1 8 pts. 8,742

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds, with 1-12 hydrogen bonds spanning the dimer interface. In addition, at least 75% of all polar atoms in the network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 21 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 168 residues are buried in the core of the entire complex (including the interface between monomer units).