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1174: 70 Residue Symmetric Hexamer Design: Protein Snowflakes

Closed since over 10 years ago

Intermediate Intermediate Overall Overall Design Design Symmetry Symmetry

Summary

Created
December 23, 2015
Expires
Max points
100
Description

This is a symmetric hexamer design puzzle with 70 residues; there will be six symmetric chains to manage. This puzzle includes the H-bond Network Filter, but requires that networks are at least 75% satisfied! See the puzzle comments for more details. The Baker Lab will run folding simulations on your solutions for this puzzle, and those that perform well will be synthesized in the lab. This puzzle will remain open for two weeks.

BONUS: It's winter here in Seattle, but we still haven't seen any snow! Submit your best "protein snowflake" using the Upload for Scientists button and the Foldit team will post their favorite snowflakes on the blog! Check out previous Foldit protein snowflakes here!

Top groups

  1. Avatar for CHS SGF,MO 21. CHS SGF,MO 1 pt. 0
  2. Avatar for DSN @ Home 22. DSN @ Home 1 pt. 0
  1. Avatar for pvc78 41. pvc78 Lv 1 45 pts. 13,031
  2. Avatar for O Seki To 42. O Seki To Lv 1 44 pts. 13,021
  3. Avatar for Iron pet 43. Iron pet Lv 1 43 pts. 12,911
  4. Avatar for Bruno Kestemont 44. Bruno Kestemont Lv 1 42 pts. 12,893
  5. Avatar for alcor29 45. alcor29 Lv 1 41 pts. 12,888
  6. Avatar for WarpSpeed 46. WarpSpeed Lv 1 40 pts. 12,865
  7. Avatar for stomjoh 47. stomjoh Lv 1 39 pts. 12,845
  8. Avatar for Bletchley Park 48. Bletchley Park Lv 1 38 pts. 12,843
  9. Avatar for mimi 49. mimi Lv 1 37 pts. 12,759
  10. Avatar for Bautho 50. Bautho Lv 1 37 pts. 12,756

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds, with 1-12 hydrogen bonds spanning the dimer interface. In addition, at least 75% of all polar atoms in the network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 21 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 168 residues are buried in the core of the entire complex (including the interface between monomer units).