Placeholder image of a protein
Icon representing a puzzle

1187: 60 Residue Symmetric Trimer: H-Bond Networks

Closed since about 10 years ago

Intermediate Overall Design Symmetry

Summary

Created
January 28, 2016
Expires
Max points
100
Description

This symmetric design puzzle has C3 symmetry, with three symmetric chains. The Hbond Network Filter encourages players to bury satisfied Hbond networks at the interface, but note that no more than six inter-molecular Hbonds may contribute to the filter! There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for DSN @ Home 21. DSN @ Home 1 pt. 0
  2. Avatar for JCBio162 22. JCBio162 1 pt. 0
  3. Avatar for TS Biology 23. TS Biology 1 pt. 0
  1. Avatar for Scopper 41. Scopper Lv 1 35 pts. 11,912
  2. Avatar for actiasluna 42. actiasluna Lv 1 34 pts. 11,902
  3. Avatar for WarpSpeed 43. WarpSpeed Lv 1 33 pts. 11,883
  4. Avatar for matosfran 44. matosfran Lv 1 32 pts. 11,883
  5. Avatar for isaksson 45. isaksson Lv 1 31 pts. 11,864
  6. Avatar for smilingone 46. smilingone Lv 1 30 pts. 11,860
  7. Avatar for alcor29 47. alcor29 Lv 1 29 pts. 11,858
  8. Avatar for phi16 48. phi16 Lv 1 28 pts. 11,855
  9. Avatar for WBarme1234 49. WBarme1234 Lv 1 27 pts. 11,844
  10. Avatar for Bletchley Park 50. Bletchley Park Lv 1 27 pts. 11,840

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds. Up to 6 hydrogen bonds may span all interfaces. In addition, at least 75% of all polar atoms in a network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 18 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 66 residues are buried in the core of the entire complex (including the interface between monomer units).