Placeholder image of a protein
Icon representing a puzzle

1187: 60 Residue Symmetric Trimer: H-Bond Networks

Closed since about 10 years ago

Intermediate Overall Design Symmetry

Summary

Created
January 28, 2016
Expires
Max points
100
Description

This symmetric design puzzle has C3 symmetry, with three symmetric chains. The Hbond Network Filter encourages players to bury satisfied Hbond networks at the interface, but note that no more than six inter-molecular Hbonds may contribute to the filter! There are several other filters in effect; see the puzzle comments for details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 12,707
  2. Avatar for Contenders 2. Contenders 80 pts. 12,614
  3. Avatar for Beta Folders 3. Beta Folders 63 pts. 12,576
  4. Avatar for Go Science 4. Go Science 49 pts. 12,565
  5. Avatar for L'Alliance Francophone 5. L'Alliance Francophone 37 pts. 12,426
  6. Avatar for Void Crushers 6. Void Crushers 28 pts. 12,406
  7. Avatar for Gargleblasters 7. Gargleblasters 21 pts. 12,195
  8. Avatar for Deleted group 8. Deleted group pts. 12,043
  9. Avatar for HMT heritage 9. HMT heritage 11 pts. 11,724
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 8 pts. 10,901
  1. Avatar for sean4046 121. sean4046 Lv 1 2 pts. 8,426
  2. Avatar for demeter900 122. demeter900 Lv 1 2 pts. 8,365
  3. Avatar for Psych0Active 123. Psych0Active Lv 1 2 pts. 7,912
  4. Avatar for Mike Lewis 124. Mike Lewis Lv 1 2 pts. 7,743
  5. Avatar for NameChangeNeeded01 125. NameChangeNeeded01 Lv 1 2 pts. 7,386
  6. Avatar for kitek314_pl 126. kitek314_pl Lv 1 2 pts. 7,350
  7. Avatar for opiorfina 127. opiorfina Lv 1 1 pt. 7,051
  8. Avatar for Superphosphate 128. Superphosphate Lv 1 1 pt. 6,922
  9. Avatar for mitarcher 129. mitarcher Lv 1 1 pt. 6,882
  10. Avatar for Jajaboman 130. Jajaboman Lv 1 1 pt. 6,617

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

HBond Network: Rewards networks comprising at least three hydrogen bonds. Up to 6 hydrogen bonds may span all interfaces. In addition, at least 75% of all polar atoms in a network must make hydrogen bonds.

Core Existence: Monomer: Ensures that at least 18 residues are buried in the core of the monomer unit.

Core Existence: Complex: Ensures that at least 66 residues are buried in the core of the entire complex (including the interface between monomer units).