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1199: 70 Residue Monomer Design

Closed since about 10 years ago

Intermediate Overall Design

Summary

Created
February 25, 2016
Expires
Max points
100
Description

This is a basic 70 residue design puzzle with slightly up-weighted backbone scoring. Players should take care that all residues have a good backbone score! See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

retiredmichael Lv 1

you probably used auto structures, when you do it will turn segment70 into a ligand. been a long time issue with auto structure. Loci has been looking at it for months and has even modified a few recipes to deal with it.