Placeholder image of a protein
Icon representing a puzzle

1217: 80 Residue Monomer Design: Residue Count Filter

Closed since almost 10 years ago

Intermediate Overall Design

Summary

Created
April 07, 2016
Expires
Max points
100
Description

This design puzzle features a new filter: the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 80 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Italiani Al Lavoro 11. Italiani Al Lavoro 3 pts. 9,914
  2. Avatar for SETI.Germany 12. SETI.Germany 2 pts. 9,422
  3. Avatar for BOINC@Poland 13. BOINC@Poland 1 pt. 9,234
  4. Avatar for Richard Dawkins Foundation 14. Richard Dawkins Foundation 1 pt. 9,115
  5. Avatar for D001x Med Chem MOOC 15. D001x Med Chem MOOC 1 pt. 9,076
  6. Avatar for freefolder 16. freefolder 1 pt. 9,008
  7. Avatar for Deleted group 17. Deleted group pts. 8,784
  8. Avatar for DSN @ Home 18. DSN @ Home 1 pt. 7,248
  9. Avatar for Natural Abilities 19. Natural Abilities 1 pt. 4,983
  10. Avatar for Window Group 20. Window Group 1 pt. 0
  1. Avatar for isaksson 21. isaksson Lv 1 59 pts. 10,353
  2. Avatar for KarenCH 22. KarenCH Lv 1 58 pts. 10,352
  3. Avatar for gmn 23. gmn Lv 1 56 pts. 10,342
  4. Avatar for stomjoh 24. stomjoh Lv 1 55 pts. 10,336
  5. Avatar for frood66 25. frood66 Lv 1 53 pts. 10,325
  6. Avatar for nicobul 26. nicobul Lv 1 52 pts. 10,322
  7. Avatar for WarpSpeed 27. WarpSpeed Lv 1 50 pts. 10,311
  8. Avatar for Skippysk8s 28. Skippysk8s Lv 1 49 pts. 10,306
  9. Avatar for smilingone 29. smilingone Lv 1 47 pts. 10,300
  10. Avatar for bertro 30. bertro Lv 1 46 pts. 10,290

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 80 residue limit. Players may insert up to 10 extra residues.