Placeholder image of a protein
Icon representing a puzzle

1217: 80 Residue Monomer Design: Residue Count Filter

Closed since almost 10 years ago

Intermediate Overall Design

Summary

Created
April 07, 2016
Expires
Max points
100
Description

This design puzzle features a new filter: the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 80 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 10,543
  2. Avatar for Contenders 2. Contenders 77 pts. 10,498
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 58 pts. 10,489
  4. Avatar for Beta Folders 4. Beta Folders 43 pts. 10,471
  5. Avatar for Gargleblasters 5. Gargleblasters 31 pts. 10,442
  6. Avatar for Void Crushers 6. Void Crushers 22 pts. 10,391
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 15 pts. 10,322
  8. Avatar for HMT heritage 8. HMT heritage 11 pts. 10,210
  9. Avatar for Deleted group 9. Deleted group pts. 10,106
  10. Avatar for FoldIt@Netherlands 10. FoldIt@Netherlands 5 pts. 10,028
  1. Avatar for sylvieh 181. sylvieh Lv 1 1 pt. 0
  2. Avatar for Cbob 182. Cbob Lv 1 1 pt. 0
  3. Avatar for AeonFluff 183. AeonFluff Lv 1 1 pt. 0
  4. Avatar for jflat06 184. jflat06 Lv 1 1 pt. 0
  5. Avatar for telloju 185. telloju Lv 1 1 pt. 0
  6. Avatar for kosyumote 186. kosyumote Lv 1 1 pt. 0
  7. Avatar for Bletchley Park 187. Bletchley Park Lv 1 1 pt. 0
  8. Avatar for DodoBird 188. DodoBird Lv 1 1 pt. 0
  9. Avatar for pmthomson90 189. pmthomson90 Lv 1 1 pt. 0
  10. Avatar for inkycatz 190. inkycatz Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 80 residue limit. Players may insert up to 10 extra residues.