Placeholder image of a protein
Icon representing a puzzle

1220: 70 Residue Monomer Design: Residue Count Filter

Closed since almost 10 years ago

Intermediate Overall Design

Summary

Created
April 14, 2016
Expires
Max points
100
Description

This design puzzle features a new filter: the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 70 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Contenders
    1. Contenders
    100 pts. 10,350
  2. Avatar for Beta Folders 2. Beta Folders 77 pts. 10,291
  3. Avatar for Go Science 3. Go Science 58 pts. 10,249
  4. Avatar for Void Crushers 4. Void Crushers 43 pts. 10,202
  5. Avatar for L'Alliance Francophone 5. L'Alliance Francophone 31 pts. 10,196
  6. Avatar for Anthropic Dreams 6. Anthropic Dreams 22 pts. 10,192
  7. Avatar for Gargleblasters 7. Gargleblasters 15 pts. 10,192
  8. Avatar for HMT heritage 8. HMT heritage 11 pts. 10,136
  9. Avatar for Deleted group 9. Deleted group pts. 9,719
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 5 pts. 9,606
  1. Avatar for MaartenDesnouck 21. MaartenDesnouck Lv 1 2 pts. 10,188
  2. Avatar for phi16 22. phi16 Lv 1 2 pts. 10,188
  3. Avatar for Mike Lewis 23. Mike Lewis Lv 1 1 pt. 10,187
  4. Avatar for Blipperman 24. Blipperman Lv 1 1 pt. 10,183
  5. Avatar for Skippysk8s 25. Skippysk8s Lv 1 1 pt. 10,174
  6. Avatar for Jim Fraser 26. Jim Fraser Lv 1 1 pt. 10,169
  7. Avatar for gmn 27. gmn Lv 1 1 pt. 10,166
  8. Avatar for alwen 28. alwen Lv 1 1 pt. 10,159
  9. Avatar for alcor29 29. alcor29 Lv 1 1 pt. 10,155
  10. Avatar for jamiexq 30. jamiexq Lv 1 1 pt. 10,142

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 70 residue limit. Players may insert up to 10 extra residues.