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1221: Disordered Electron Density: Round 1

Closed since almost 10 years ago

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Summary

Created
April 17, 2016
Expires
Max points
100
Description

NOTE: Because many players have had trouble playing this puzzle, the puzzle has been made worth zero points, and it will not contribute to player rankings. However, this puzzle is still of unique scientific interest, and we encourage players to work on it if they are able!



This is a big one! This electron density puzzle features two proteins: the first is a large well-ordered helical protein that is mostly frozen in place. This binder protein has two flexible loops that bind a second, mostly disordered, substrate protein. The substrate protein is provided here as an extended chain, and is completely flexible. We know that the substrate protein is bound to the binder protein somewhere in this crystal structure. But it seems that the substrate is able to adopt several different shapes, making the electron density very difficult to interpret. We’re asking Foldit players to help us find the ways that the substrate protein can bind to the binder protein! Fold up the extended chain and dock it next to the flexible loops of the binder to improve your score!

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Comments

ViJay7019 Lv 1

Checking "disable network timeouts" on the login screen let it download without the timeout message.

But then it crashes into a grinding halt

Susume Lv 1

Same here: disabling network timeouts prevents the server timeout message, but the game loads the 1221 score boards (can't tell if it loads the protein, as I can't see the protein on the screen) and then promptly crashes. Win 7 devprev.

Also, before crashing it says we have over 52 million days left on the puzzle (and 19 hours).

grogar7 Lv 1

I did not have any errors opening this puzzle (although it did take a while to load) and it seems to be running fine. And I have an older Core i5 (first generation) ASUS running Windows 10. Go figure …

TomTaylor Lv 1

Yesterday my fourth attempt to open the puzzle crashed in about 1/2 second. Today I got to the screen initializing before crashing. Susume reported over 52 million days left, I only get 48,798,575 days 1 hours left till the puzzle expires. What gives?

Visual Studio reports the following error:

Unhandled exception at 0x75D2DAD8 in Foldit.exe: Microsoft C++ exception: std::bad_alloc at memory location 0x0018F298.

bkoep Staff Lv 1

Yes, in addition to protein, this crystal structure does include some well-ordered small molecules. The small spheres represent Zn atoms, and the ringed molecules are imidazole (which is very similar to the side chain of histidine). These small molecules occupy strong density in the electron density map, but they are frozen in place, and can mostly be ignored in this puzzle.

Bruno Kestemont Lv 1

trying to share= > crash
trying to open it again 20 times= always crash
restard computer: crash on all attempts
It's like this computer is definitively not able to open it anymore.
==================

Loading on another computer (also Windows): OK first time, crash on other attempts

Loading on a new DEVPREV same computer: OK