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1221: Disordered Electron Density: Round 1

Closed since almost 10 years ago

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Summary

Created
April 17, 2016
Expires
Max points
100
Description

NOTE: Because many players have had trouble playing this puzzle, the puzzle has been made worth zero points, and it will not contribute to player rankings. However, this puzzle is still of unique scientific interest, and we encourage players to work on it if they are able!



This is a big one! This electron density puzzle features two proteins: the first is a large well-ordered helical protein that is mostly frozen in place. This binder protein has two flexible loops that bind a second, mostly disordered, substrate protein. The substrate protein is provided here as an extended chain, and is completely flexible. We know that the substrate protein is bound to the binder protein somewhere in this crystal structure. But it seems that the substrate is able to adopt several different shapes, making the electron density very difficult to interpret. We’re asking Foldit players to help us find the ways that the substrate protein can bind to the binder protein! Fold up the extended chain and dock it next to the flexible loops of the binder to improve your score!

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Comments

jamiexq Lv 1

Was able to play puzzle until servers went down - and now cannot get it to open again - crashes foldit win 7 main

gitwut Lv 1

As I suggested earlier, this puzzle should be closed and re-opened as a devprev puzzle. It is unworkable for too many people.

O Seki To Lv 1

Just as others said it opened once without problem, then never again. Neither in main nor in deprev clients. Tried on three different computers at least 20 times: Win 7, Win 8 even on Vista. The one with Win 8 has 32 GB memory and a 3rd gen i7 CPU - the crash cannot be a resource problem.
I second gitwut suggestion: Close it and re-post as a devprev puzzle, unless it can be fixed and made playable for everyone.

LociOiling Lv 1

One client kept crashing on opening the puzzle.

After some experimentation, I tried deleting the the autosave files under

foldit\puzzles\002002315*userid\autosave.ir_solution

where foldit is the foldit install folder, 002002315 is the nodeid of puzzle 1221, userid is your numeric userid (it should be the only directory at this level), and autosave*.ir_solution is all the autosaved solution files.

I hadn't done anything on this client, so the autosaved files were worthless.

Deleting these files allowed the client to open the puzzle without crashing.

I suspect this files were corrupted in one of the previous crashes.

Mike Lewis Lv 1

Yesterday loaded fine (albeit a bit slowly) then was fine until server blip. Today can't open it and it crashes. Loci's solution sadly didn't work for me unless I delete all the quicksaves as well, then it does open although the puzzle has been reset. Not ideal…

grogar7 Lv 1

1221 was playing without problems 10 minutes ago. I saved current solution and tried to open an earlier saved solution. Immediate crash!

Now I cannot reload the puzzle, even with 'disable server timeouts' checked.

I agree with those who say, "Get rid of this one until problem is solved."

Bautho Lv 1

Exactly the same for me… It ran smoothly until I started to try sharing my solution. Now I cannot play it at all anymore. The other puzzles are working, but this won't open. :(

inkycatz Lv 1

While it may be a memory associated issue, or maybe not, the team has passed along these helpful suggestions:

Closing other programs.
Start the puzzle on a fresh client, so that it has loaded the minimal set of data in to memory.
Upgrading any hardware, if possible. (We know that's probably not a great solution or all that practical for a lot of you so we put it last.)

In the meantime, we appreciate all the reports and your patience with this puzzle!