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1223: 75 Residue Monomer Design: Residue Count Filter

Closed since almost 10 years ago

Intermediate Intermediate Overall Overall Design Design

Summary

Created
April 21, 2016
Expires
Max points
100
Description

This design puzzle features a new filter: the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 75 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for SAU_CHEM_319_SP_2016 21. SAU_CHEM_319_SP_2016 1 pt. 0
  2. Avatar for Cannabis Crew 22. Cannabis Crew 1 pt. 0
  3. Avatar for Window Group 23. Window Group 1 pt. 0
  1. Avatar for The_Lunar_1 121. The_Lunar_1 Lv 1 2 pts. 8,139
  2. Avatar for Wheeler22 122. Wheeler22 Lv 1 1 pt. 8,066
  3. Avatar for isantheautumn 123. isantheautumn Lv 1 1 pt. 7,924
  4. Avatar for Arne Heessels 124. Arne Heessels Lv 1 1 pt. 7,863
  5. Avatar for Flagg65a 125. Flagg65a Lv 1 1 pt. 7,859
  6. Avatar for lamoille 126. lamoille Lv 1 1 pt. 7,820
  7. Avatar for 01010011111 127. 01010011111 Lv 1 1 pt. 7,816
  8. Avatar for Tump 128. Tump Lv 1 1 pt. 7,782
  9. Avatar for Stephen R 129. Stephen R Lv 1 1 pt. 7,666
  10. Avatar for doctaven 130. doctaven Lv 1 1 pt. 7,662

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 75 residue limit. Players may insert up to 10 extra residues.