Placeholder image of a protein
Icon representing a puzzle

1226: 85 Residue Monomer Design: Residue Count Filter

Closed since almost 10 years ago

Intermediate Overall Design

Summary

Created
April 29, 2016
Expires
Max points
100
Description

This design puzzle features a new filter: the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 85 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Contenders
    1. Contenders
    100 pts. 10,689
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 78 pts. 10,665
  3. Avatar for Go Science 3. Go Science 60 pts. 10,646
  4. Avatar for Beta Folders 4. Beta Folders 45 pts. 10,597
  5. Avatar for Void Crushers 5. Void Crushers 33 pts. 10,492
  6. Avatar for Gargleblasters 6. Gargleblasters 24 pts. 10,491
  7. Avatar for HMT heritage 7. HMT heritage 17 pts. 10,427
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 12 pts. 10,343
  9. Avatar for Russian team 9. Russian team 8 pts. 10,186
  10. Avatar for D001x Med Chem MOOC 10. D001x Med Chem MOOC 6 pts. 9,628
  1. Avatar for jvmm18 141. jvmm18 Lv 1 1 pt. 6,210
  2. Avatar for HMK 142. HMK Lv 1 1 pt. 5,950
  3. Avatar for zalbitr 143. zalbitr Lv 1 1 pt. 5,641
  4. Avatar for Hollinas 144. Hollinas Lv 1 1 pt. 5,088
  5. Avatar for lamoille 145. lamoille Lv 1 1 pt. 4,820
  6. Avatar for ferzle 146. ferzle Lv 1 1 pt. 4,797
  7. Avatar for Truncheon Luncheon 147. Truncheon Luncheon Lv 1 1 pt. 4,770
  8. Avatar for Soggy Doglog 148. Soggy Doglog Lv 1 1 pt. 4,766
  9. Avatar for Jim Fraser 149. Jim Fraser Lv 1 1 pt. 4,762
  10. Avatar for TJOK fan 150. TJOK fan Lv 1 1 pt. 4,730

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 85 residue limit. Players may insert up to 10 extra residues.