Placeholder image of a protein
Icon representing a puzzle

1226: 85 Residue Monomer Design: Residue Count Filter

Closed since almost 10 years ago

Intermediate Overall Design

Summary

Created
April 29, 2016
Expires
Max points
100
Description

This design puzzle features a new filter: the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 85 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Contenders
    1. Contenders
    100 pts. 10,689
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 78 pts. 10,665
  3. Avatar for Go Science 3. Go Science 60 pts. 10,646
  4. Avatar for Beta Folders 4. Beta Folders 45 pts. 10,597
  5. Avatar for Void Crushers 5. Void Crushers 33 pts. 10,492
  6. Avatar for Gargleblasters 6. Gargleblasters 24 pts. 10,491
  7. Avatar for HMT heritage 7. HMT heritage 17 pts. 10,427
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 12 pts. 10,343
  9. Avatar for Russian team 9. Russian team 8 pts. 10,186
  10. Avatar for D001x Med Chem MOOC 10. D001x Med Chem MOOC 6 pts. 9,628
  1. Avatar for KarenCH 51. KarenCH Lv 1 24 pts. 10,106
  2. Avatar for nicobul 52. nicobul Lv 1 23 pts. 10,104
  3. Avatar for smilingone 53. smilingone Lv 1 22 pts. 10,087
  4. Avatar for ViJay7019 54. ViJay7019 Lv 1 21 pts. 10,085
  5. Avatar for hansvandenhof 55. hansvandenhof Lv 1 21 pts. 10,043
  6. Avatar for DodoBird 56. DodoBird Lv 1 20 pts. 10,027
  7. Avatar for g_b 57. g_b Lv 1 19 pts. 9,997
  8. Avatar for toshiue 58. toshiue Lv 1 19 pts. 9,973
  9. Avatar for tallguy-13088 59. tallguy-13088 Lv 1 18 pts. 9,964
  10. Avatar for Mike Cassidy 60. Mike Cassidy Lv 1 17 pts. 9,920

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 85 residue limit. Players may insert up to 10 extra residues.