1233: 90 Residue Monomer Design: Residue Count Filter

Closed since almost 10 years ago

Summary

• Created: May 12, 2016
• Expires: May 19, 2016 at 23:00 UTC
• Max points: 100

Description

This design puzzle features a new filter: the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 90 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Contenders 100 pts. 10,769
• 2. Beta Folders 71 pts. 10,749
• 3. Anthropic Dreams 49 pts. 10,733
• 4. Go Science 33 pts. 10,692
• 5. Gargleblasters 22 pts. 10,574
• 6. Void Crushers 14 pts. 10,490
• 7. L'Alliance Francophone 8 pts. 10,476
• 8. HMT heritage 5 pts. 10,433
• 9. D001x Med Chem MOOC 3 pts. 10,275
• 10. xkcd 2 pts. 10,199

Top evolvers

• 1. Bletchley Park 100 pts. 10,769
• 2. gitwut 85 pts. 10,751
• 3. reefyrob 72 pts. 10,749
• 4. Deleted player pts. 10,747
• 5. TomTaylor 51 pts. 10,745
• 6. LociOiling 42 pts. 10,745
• 7. smilingone 35 pts. 10,743
• 8. Galaxie 28 pts. 10,731
• 9. lamoille 23 pts. 10,730
• 10. mimi 19 pts. 10,729

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 90 residue limit. Players may insert up to 10 extra residues.