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1236: 80 Residue Monomer Design: Residue Count Filter

Closed since almost 10 years ago

Intermediate Overall Design

Summary

Created
May 19, 2016
Expires
Max points
100
Description

This design puzzle features a new filter: the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 80 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

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Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 80 residue limit. Players may insert up to 10 extra residues.

LociOiling Lv 1

Contacts earn a weighted bonus. The formula for a made contact's bonus is:

bonus = 50 * contactmap.GetHeat ( xx, yy )

where xx and yy are the in-contact segments.