Placeholder image of a protein
Icon representing a puzzle

1239: 65 Residue Monomer Design: Residue Count Filter

Closed since about 10 years ago

Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design Design Design Design

Summary

Created
May 26, 2016
Expires
Max points
100
Description

In this design puzzle, the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 65 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for BCC 11. BCC 1 pt. 9,165
  2. Avatar for SETI.Germany 12. SETI.Germany 1 pt. 8,163
  3. Avatar for DSN @ Home 13. DSN @ Home 1 pt. 7,020
  4. Avatar for LCC Organic Chemistry 14. LCC Organic Chemistry 1 pt. 0
  5. Avatar for SAA Biology 15. SAA Biology 1 pt. 0
  1. Avatar for deLaCeiba 51. deLaCeiba Lv 1 15 pts. 9,623
  2. Avatar for Iron pet 52. Iron pet Lv 1 14 pts. 9,618
  3. Avatar for jobo0502 53. jobo0502 Lv 1 14 pts. 9,617
  4. Avatar for SKSbell 54. SKSbell Lv 1 13 pts. 9,577
  5. Avatar for temandocorreo 55. temandocorreo Lv 1 12 pts. 9,552
  6. Avatar for Acida-2 56. Acida-2 Lv 1 12 pts. 9,535
  7. Avatar for weitzen 57. weitzen Lv 1 11 pts. 9,527
  8. Avatar for Squirrely 58. Squirrely Lv 1 11 pts. 9,516
  9. Avatar for xavierhochart 59. xavierhochart Lv 1 10 pts. 9,509
  10. Avatar for alwen 60. alwen Lv 1 10 pts. 9,498

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 65 residue limit. Players may insert up to 10 extra residues.