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1242: 85 Residue Monomer Design: Residue Count Filter

Closed since almost 10 years ago

Summary

Created: June 03, 2016
Expires: June 10, 2016 at 23:00 UTC
Max points: 100

Description

In this design puzzle, the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 85 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

11. SETI.Germany 1 pt. 8,246
12. Deleted group pts. 7,743
13. BCC 1 pt. 6,835
14. DSN @ Home 1 pt. 6,830
15. PSU Berks BMB 465 1 pt. 0
16. Window Group 1 pt. 0

101. NinguLilium Lv 1 1 pt. 8,192
102. dbuske Lv 1 1 pt. 8,151
103. Wheeler22 Lv 1 1 pt. 8,023
104. tomespen Lv 1 1 pt. 7,900
105. Alistair69 Lv 1 1 pt. 7,891
106. Cerzax Lv 1 1 pt. 7,812
107. Dantoto Lv 1 1 pt. 7,743
108. NotJim99 Lv 1 1 pt. 7,691
109. froggs554 Lv 1 1 pt. 7,686
110. emdee314 Lv 1 1 pt. 7,664

Comments

bkoep Staff Lv 1

June 03, 2016

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 85 residue limit. Players may insert up to 10 extra residues.