1245: 70 Residue Monomer Design: Residue Count Filter

Closed since almost 10 years ago

Summary

• Created: June 11, 2016
• Expires: June 17, 2016 at 23:00 UTC
• Max points: 100

Description

In this design puzzle, the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 70 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 11. BOINC@Poland 2 pts. 8,803
• 12. SETI.Germany 1 pt. 8,458
• 13. BCC 1 pt. 8,148
• 14. freefolder 1 pt. 7,445
• 15. DSN @ Home 1 pt. 7,392
• 16. Advanced Protein Science 2 - 2016 1 pt. 0
• 17. Czech National Team 1 pt. 0
• 18. xkcd 1 pt. 0
• 19. Deleted group pts. 0

Top evolvers

• 1. mimi 100 pts. 10,323
• 2. Bletchley Park 86 pts. 10,320
• 3. dembones 74 pts. 10,319
• 4. TomTaylor 63 pts. 10,318
• 5. gitwut 53 pts. 10,317
• 6. smilingone 44 pts. 10,292
• 7. retiredmichael 37 pts. 10,285
• 8. Deleted player pts. 10,284
• 9. CharlieFortsConscience 25 pts. 10,277
• 10. reefyrob 21 pts. 10,265

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 70 residue limit. Players may insert up to 10 extra residues.