1245: 70 Residue Monomer Design: Residue Count Filter

Closed since almost 10 years ago

Summary

• Created: June 11, 2016
• Expires: June 17, 2016 at 23:00 UTC
• Max points: 100

Description

In this design puzzle, the Residue Count filter incurs a penalty when a player inserts extra residues beyond the 70 residue limit. The filter is intended to give players the flexibility to temporarily add residues to a design-in-progress. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 11. BOINC@Poland 2 pts. 8,803
• 12. SETI.Germany 1 pt. 8,458
• 13. BCC 1 pt. 8,148
• 14. freefolder 1 pt. 7,445
• 15. DSN @ Home 1 pt. 7,392
• 16. Advanced Protein Science 2 - 2016 1 pt. 0
• 17. Czech National Team 1 pt. 0
• 18. xkcd 1 pt. 0
• 19. Deleted group pts. 0

Top soloists

• 41. dembones 23 pts. 9,903
• 42. Fetztastic 22 pts. 9,902
• 43. Vinara 21 pts. 9,887
• 44. Anfinsen_slept_here 20 pts. 9,817
• 45. DodoBird 19 pts. 9,805
• 46. Mike Cassidy 19 pts. 9,770
• 47. Superphosphate 18 pts. 9,763
• 48. georg137 17 pts. 9,738
• 49. senor pit 16 pts. 9,730
• 50. weitzen 15 pts. 9,703

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 70 residue limit. Players may insert up to 10 extra residues.