Placeholder image of a protein
Icon representing a puzzle

1258: Tuberculosis Challenge - Phase 1

Closed since almost 10 years ago

Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Overall Overall Overall Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction Prediction

Summary

Created
July 11, 2016
Expires
Max points
100
Description

This puzzle starts with an unfolded sequence with secondary structure assigned from PSIPRED. The target protein is LepB and is currently being investigated for drug discovery against Tuberculosis (TB). TB is caused by the bacillus Mycobacterium tuberculosis and has killed more than 1.5 million people in 2014. Right now, no crystal structure exists for this target. Models created by Foldit players will be used to help solve the structure when crystals become available.

Top groups

  1. Avatar for Contenders
    1. Contenders
    100 pts. 9,670
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 73 pts. 9,563
  3. Avatar for Go Science 3. Go Science 52 pts. 9,497
  4. Avatar for Gargleblasters 4. Gargleblasters 36 pts. 9,362
  5. Avatar for Deleted group 5. Deleted group pts. 9,235
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 16 pts. 9,218
  7. Avatar for Void Crushers 7. Void Crushers 10 pts. 9,063
  8. Avatar for Beta Folders 8. Beta Folders 6 pts. 9,058
  9. Avatar for Italiani Al Lavoro 9. Italiani Al Lavoro 4 pts. 8,255
  10. Avatar for HMT heritage 10. HMT heritage 2 pts. 7,801
  1. Avatar for gitwut
    1. gitwut Lv 1
    100 pts. 9,615
  2. Avatar for Galaxie 2. Galaxie Lv 1 98 pts. 9,547
  3. Avatar for Susume 3. Susume Lv 1 96 pts. 9,517
  4. Avatar for Bruno Kestemont 4. Bruno Kestemont Lv 1 94 pts. 9,494
  5. Avatar for Deleted player 5. Deleted player pts. 9,403
  6. Avatar for dembones 6. dembones Lv 1 90 pts. 9,379
  7. Avatar for MurloW 7. MurloW Lv 1 88 pts. 9,329
  8. Avatar for brow42 8. brow42 Lv 1 86 pts. 9,309
  9. Avatar for tokens 9. tokens Lv 1 84 pts. 9,272
  10. Avatar for grogar7 10. grogar7 Lv 1 82 pts. 9,261

Comments

Susume Lv 1

Hi Batz,

There is no evidence that there are disulfide bonds in LepB. One of the scientist who is working on this problem responded:

To predict if the protein forms disulfide bonds scientists look at the protein residency in a particular cellular compartment and its oxidative properties.

  1. You check what kind of bacteria TB is gram+ or gram-
  2. Predict protein compartment
  3. Check for presence of disulfides

Bautho Lv 1

This puzzle has about twice the usual number of amino acids in it.
Why not give us about twice the usual amount of time to work on it?
Also, please let us load this puzzle's solutions into future puzzles.

Thanks!

spvincent Lv 1

Hi Batz,

There is no evidence that there are disulfide bonds in LepB. One of the scientist who is working on this problem responded:

To predict if the protein forms disulfide bonds scientists look at the protein residency in a particular cellular compartment and its oxidative properties.

  1. You check what kind of bacteria TB is gram+ or gram-
  2. Predict protein compartment
  3. Check for presence of disulfides

free_radical Lv 1

Hi Batz,

There is no evidence that there are disulfide bonds in LepB. One of the scientist who is working on this problem responded:

To predict if the protein forms disulfide bonds scientists look at the protein residency in a particular cellular compartment and its oxidative properties.

  1. You check what kind of bacteria TB is gram+ or gram-
  2. Predict protein compartment
  3. Check for presence of disulfides

jeff101 Lv 1

Hi Batz,

There is no evidence that there are disulfide bonds in LepB. One of the scientist who is working on this problem responded:

To predict if the protein forms disulfide bonds scientists look at the protein residency in a particular cellular compartment and its oxidative properties.

  1. You check what kind of bacteria TB is gram+ or gram-
  2. Predict protein compartment
  3. Check for presence of disulfides

jeff101 Lv 1

Hi Jeff101,

I have no problem extending the puzzle for a week. Phase 2 will include models from phase 1 to work on. I know this is a hard puzzle (I have been playing it too, and for the life of me I cant get my score that high…).

free_radical Lv 1

Hi Batz,

There is no evidence that there are disulfide bonds in LepB. One of the scientist who is working on this problem responded:

To predict if the protein forms disulfide bonds scientists look at the protein residency in a particular cellular compartment and its oxidative properties.

  1. You check what kind of bacteria TB is gram+ or gram-
  2. Predict protein compartment
  3. Check for presence of disulfides

free_radical Lv 1

Hi Batz,

There is no evidence that there are disulfide bonds in LepB. One of the scientist who is working on this problem responded:

To predict if the protein forms disulfide bonds scientists look at the protein residency in a particular cellular compartment and its oxidative properties.

  1. You check what kind of bacteria TB is gram+ or gram-
  2. Predict protein compartment
  3. Check for presence of disulfides

jeff101 Lv 1

Hi Batz,

There is no evidence that there are disulfide bonds in LepB. One of the scientist who is working on this problem responded:

To predict if the protein forms disulfide bonds scientists look at the protein residency in a particular cellular compartment and its oxidative properties.

  1. You check what kind of bacteria TB is gram+ or gram-
  2. Predict protein compartment
  3. Check for presence of disulfides

jeff101 Lv 1

Hi Jeff101,

I have no problem extending the puzzle for a week. Phase 2 will include models from phase 1 to work on. I know this is a hard puzzle (I have been playing it too, and for the life of me I cant get my score that high…).