Placeholder image of a protein
Icon representing a puzzle

1275: 65 Residue Monomer Design: Helical Bundles

Closed since over 9 years ago

Intermediate Overall Design

Summary

Created
August 22, 2016
Expires
Max points
100
Description

This is a basic 65 residue design puzzle with no secondary structure filter—helical bundles welcome! The Ideal Loops Filter is meant to encourage the use of the Ideal Loops that are displayed in the Rama Map. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for SETI.Germany 11. SETI.Germany 1 pt. 8,472
  2. Avatar for Mojo Risin' 12. Mojo Risin' 1 pt. 6,858
  3. Avatar for freefolder 13. freefolder 1 pt. 6,752
  4. Avatar for Italiani Al Lavoro 14. Italiani Al Lavoro 1 pt. 6,729
  5. Avatar for DSN @ Home 15. DSN @ Home 1 pt. 2,962
  6. Avatar for Window Group 16. Window Group 1 pt. 0
  1. Avatar for alrianne 81. alrianne Lv 1 4 pts. 8,688
  2. Avatar for Deleted player 82. Deleted player pts. 8,679
  3. Avatar for SouperGenious 83. SouperGenious Lv 1 3 pts. 8,669
  4. Avatar for pfirth 84. pfirth Lv 1 3 pts. 8,627
  5. Avatar for kvasirthewise 85. kvasirthewise Lv 1 3 pts. 8,619
  6. Avatar for mirjamvandelft 86. mirjamvandelft Lv 1 3 pts. 8,606
  7. Avatar for parsnip 87. parsnip Lv 1 3 pts. 8,594
  8. Avatar for Merf 88. Merf Lv 1 3 pts. 8,593
  9. Avatar for joaniegirl 89. joaniegirl Lv 1 2 pts. 8,570
  10. Avatar for rezaefar 90. rezaefar Lv 1 2 pts. 8,558

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 65 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."