1279: 85 Residue Monomer Design: Helical Bundles

Closed since over 9 years ago

Summary

• Created: September 01, 2016
• Expires: September 08, 2016 at 23:00 UTC
• Max points: 100

Description

This is a basic 85 residue design puzzle with no secondary structure filter—helical bundles welcome! The Ideal Loops Filter is meant to encourage the use of the Ideal Loops that are displayed in the Rama Map. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

• 1. Contenders 100 pts. 10,323
• 2. Beta Folders 68 pts. 10,292
• 3. Anthropic Dreams 44 pts. 10,285
• 4. Go Science 27 pts. 10,273
• 5. Gargleblasters 16 pts. 10,250
• 6. Void Crushers 9 pts. 10,244
• 7. L'Alliance Francophone 5 pts. 10,204
• 8. HMT heritage 3 pts. 9,743
• 9. Deleted group pts. 9,179
• 10. freefolder 1 pt. 8,452

Top soloists

• 11. gitwut 76 pts. 10,226
• 12. actiasluna 74 pts. 10,224
• 13. pmdpmd 72 pts. 10,204
• 14. reefyrob 70 pts. 10,203
• 15. Deleted player pts. 10,187
• 16. tokens 66 pts. 10,159
• 17. TomTaylor 64 pts. 10,158
• 18. gmn 62 pts. 10,157
• 19. Scopper 60 pts. 10,145
• 20. Bletchley Park 58 pts. 10,144

Comments

[bkoep]

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 85 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

[drumpeter18yrs9yrs]

I don't get it. If we're given the freedom to insert residues, why are we being penalized? Wouldn't it make more sense to take away the ability to insert residues?

This is just something that I've been wondering for a long time. If this is the wrong place to say this, my deepest apologies.

[Skippysk8s]

Drum – I might use this to tweak the length of helices, sheets or loops easily and adjust without redoing whole fold. Since I'm slow at hand folding, I might add somewhere and subtract elsewhere. Can leave an ideal loop in place if I manage to find one :)