Placeholder image of a protein
Icon representing a puzzle

1299: 85 Residue Monomer Design: No Rebuilding!

Closed since over 9 years ago

Intermediate Overall Design

Summary


Created
October 24, 2016
Expires
Max points
100
Description

This puzzle is similar to recent design puzzles, but we'd like players to avoid using the Rebuild tool. We suspect that the Rebuild tool has been introducing some problematic backbones into Foldit player designs, so the Rebuild tool has been deactivated in this puzzle. In most cases, the Remix tool can be used as an alternative to Rebuild. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for xkcd 11. xkcd 4 pts. 7,824
  2. Avatar for SETI.Germany 12. SETI.Germany 3 pts. 7,638
  3. Avatar for Eὕρηκα! Heureka! 13. Eὕρηκα! Heureka! 2 pts. 7,565
  4. Avatar for FoldIt@Netherlands 14. FoldIt@Netherlands 1 pt. 7,465
  5. Avatar for freefolder 15. freefolder 1 pt. 7,300
  6. Avatar for Deleted group 16. Deleted group pts. 7,111
  7. Avatar for Russian team 17. Russian team 1 pt. 6,942
  8. Avatar for Biochem-AD17 18. Biochem-AD17 1 pt. 6,598
  9. Avatar for DSN @ Home 19. DSN @ Home 1 pt. 3,108
  10. Avatar for HMT heritage 20. HMT heritage 1 pt. 0

  1. Avatar for YeshuaLives 61. YeshuaLives Lv 1 15 pts. 9,497
  2. Avatar for meatexplosion 62. meatexplosion Lv 1 14 pts. 9,487
  3. Avatar for jamiexq 63. jamiexq Lv 1 14 pts. 9,484
  4. Avatar for alwen 64. alwen Lv 1 13 pts. 9,438
  5. Avatar for Iron pet 65. Iron pet Lv 1 13 pts. 9,436
  6. Avatar for severin333 66. severin333 Lv 1 12 pts. 9,422
  7. Avatar for Sissue 67. Sissue Lv 1 12 pts. 9,375
  8. Avatar for tallguy-13088 68. tallguy-13088 Lv 1 11 pts. 9,333
  9. Avatar for alcor29 69. alcor29 Lv 1 11 pts. 9,331
  10. Avatar for weitzen 70. weitzen Lv 1 11 pts. 9,262

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 85 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."