Placeholder image of a protein
Icon representing a puzzle

1328: 85 Residue Monomer Design: Blueprint

Closed since about 9 years ago

Intermediate Overall Design

Summary


Created
January 12, 2017
Expires
Max points
100
Description

This puzzle features the Blueprint panel, which can be accessed from the Actions menu (or the Main menu in Selection Interface). See the blog for more information. Like other recent puzzles, the Rebuild action has been disabled here; in its place we encourage players to use Remix instead. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for BOINC@Poland 11. BOINC@Poland 2 pts. 7,271
  2. Avatar for Kotocycle 12. Kotocycle 1 pt. 7,028
  3. Avatar for Team South Africa 13. Team South Africa 1 pt. 6,849
  4. Avatar for Natural Abilities 14. Natural Abilities 1 pt. 5,374
  5. Avatar for xkcd 15. xkcd 1 pt. 5,158
  6. Avatar for GUGITBIOTECH 16. GUGITBIOTECH 1 pt. 0
  7. Avatar for DSN @ Home 18. DSN @ Home 1 pt. 0
  8. Avatar for Window Group 19. Window Group 1 pt. 0

  1. Avatar for bertro
    1. bertro Lv 1
    100 pts. 10,630
  2. Avatar for markm457 2. markm457 Lv 1 97 pts. 10,615
  3. Avatar for Bruno Kestemont 3. Bruno Kestemont Lv 1 94 pts. 10,615
  4. Avatar for retiredmichael 4. retiredmichael Lv 1 90 pts. 10,610
  5. Avatar for LociOiling 5. LociOiling Lv 1 87 pts. 10,609
  6. Avatar for MurloW 6. MurloW Lv 1 84 pts. 10,604
  7. Avatar for ZeroLeak7 7. ZeroLeak7 Lv 1 81 pts. 10,601
  8. Avatar for gitwut 8. gitwut Lv 1 78 pts. 10,597
  9. Avatar for Skippysk8s 9. Skippysk8s Lv 1 75 pts. 10,597
  10. Avatar for Susume 10. Susume Lv 1 73 pts. 10,569

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 85 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."