Placeholder image of a protein
Icon representing a puzzle

1328: 85 Residue Monomer Design: Blueprint

Closed since about 9 years ago

Intermediate Overall Design

Summary


Created
January 12, 2017
Expires
Max points
100
Description

This puzzle features the Blueprint panel, which can be accessed from the Actions menu (or the Main menu in Selection Interface). See the blog for more information. Like other recent puzzles, the Rebuild action has been disabled here; in its place we encourage players to use Remix instead. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for Beta Folders 100 pts. 10,634
  2. Avatar for Gargleblasters 2. Gargleblasters 76 pts. 10,630
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 56 pts. 10,615
  4. Avatar for Go Science 4. Go Science 41 pts. 10,615
  5. Avatar for Contenders 5. Contenders 29 pts. 10,597
  6. Avatar for L'Alliance Francophone 6. L'Alliance Francophone 20 pts. 10,565
  7. Avatar for Void Crushers 7. Void Crushers 14 pts. 10,479
  8. Avatar for Deleted group 8. Deleted group pts. 9,840
  9. Avatar for Italiani Al Lavoro 9. Italiani Al Lavoro 6 pts. 9,578
  10. Avatar for Russian team 10. Russian team 4 pts. 8,672

  1. Avatar for tokens 131. tokens Lv 1 1 pt. 0
  2. Avatar for Mark A 132. Mark A Lv 1 1 pt. 0
  3. Avatar for cnhrcolemam 133. cnhrcolemam Lv 1 1 pt. 0
  4. Avatar for jflat06 134. jflat06 Lv 1 1 pt. 0
  5. Avatar for ManVsYard 135. ManVsYard Lv 1 1 pt. 0
  6. Avatar for pauldunn 136. pauldunn Lv 1 1 pt. 0
  7. Avatar for eromana 137. eromana Lv 1 1 pt. 0
  8. Avatar for cbwest 138. cbwest Lv 1 1 pt. 0
  9. Avatar for katling 139. katling Lv 1 1 pt. 0
  10. Avatar for Marvelz 140. Marvelz Lv 1 1 pt. 0

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA, and PRO residues in helices and sheets.

Residue Count: Penalizes extra residues inserted beyond the 85 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."