Placeholder image of a protein
Icon representing a puzzle

1352: 90 Residue Monomer Design: Helix Restrictions

Closed since almost 9 years ago

Intermediate Overall Design

Summary

Created
March 12, 2017
Expires
Max points
100
Description

This puzzle is similar to recent design puzzles except that we've restricted the use of SER and THR residues in α-helices. Foldit players have submitted some stellar-looking designs recently, but we are seeing quite a lot of SER and THR residues in designed helices. Recent experiments in our lab suggest that these residues are somewhat unfavorable in helices, so in this puzzle we've restricted the use of SER and THR in helical positions. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for DSN @ Home 11. DSN @ Home 2 pts. 6,772
  2. Avatar for SciOne2017 12. SciOne2017 1 pt. 4,275
  3. Avatar for xkcd 13. xkcd 1 pt. 2,267
  4. Avatar for LEC Metabolites 14. LEC Metabolites 1 pt. 979
  5. Avatar for Natural Abilities 15. Natural Abilities 1 pt. 0
  6. Avatar for Window Group 16. Window Group 1 pt. 0
  7. Avatar for Cannabis Crew 17. Cannabis Crew 1 pt. 0
  8. Avatar for freefolder 18. freefolder 1 pt. 0
  9. Avatar for Deleted group 19. Deleted group pts. 0
  1. Avatar for LociOiling
    1. LociOiling Lv 1
    100 pts. 10,817
  2. Avatar for markm457 2. markm457 Lv 1 97 pts. 10,811
  3. Avatar for actiasluna 3. actiasluna Lv 1 94 pts. 10,775
  4. Avatar for Bruno Kestemont 4. Bruno Kestemont Lv 1 92 pts. 10,772
  5. Avatar for tokens 5. tokens Lv 1 89 pts. 10,746
  6. Avatar for dcrwheeler 6. dcrwheeler Lv 1 86 pts. 10,720
  7. Avatar for ZeroLeak7 7. ZeroLeak7 Lv 1 83 pts. 10,713
  8. Avatar for fiendish_ghoul 8. fiendish_ghoul Lv 1 81 pts. 10,705
  9. Avatar for retiredmichael 9. retiredmichael Lv 1 78 pts. 10,702
  10. Avatar for reefyrob 10. reefyrob Lv 1 76 pts. 10,689

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the 90 residue limit. Players may insert up to 10 extra residues.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."