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1367: Large Monomer Design

Closed since about 9 years ago

Intermediate Intermediate Intermediate Intermediate Intermediate Intermediate Overall Overall Overall Overall Overall Overall Design Design Design Design Design Design

Summary


Created
April 17, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


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  5. Avatar for BioChem22017 17. BioChem22017 1 pt. 1,699
  6. Avatar for GUGITBIOTECH 18. GUGITBIOTECH 1 pt. 1,489
  7. Avatar for HMT heritage 19. HMT heritage 1 pt. 0

  1. Avatar for clil16 131. clil16 Lv 1 1 pt. 1,181
  2. Avatar for R2Darr 133. R2Darr Lv 1 1 pt. 0
  3. Avatar for rakei 134. rakei Lv 1 1 pt. 0
  4. Avatar for Paulo Roque 136. Paulo Roque Lv 1 1 pt. 0
  5. Avatar for eromana 137. eromana Lv 1 1 pt. 0
  6. Avatar for bkoep 138. bkoep Lv 1 1 pt. 0
  7. Avatar for Hollinas 139. Hollinas Lv 1 1 pt. 0
  8. Avatar for Bautho 140. Bautho Lv 1 1 pt. 0

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85. Players may use up to 105 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."

actiasluna Lv 1

Similar to what Susume posted for 1364. Seems to be problem between filters/scoring. Ingame group and soloist scoreboard matches website but individual scoreboard gives lower total score.