Placeholder image of a protein
Icon representing a puzzle

1370: Medium Monomer Design

Closed since almost 9 years ago

Intermediate Overall Design

Summary

Created
April 24, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Go Science
    1. Go Science
    100 pts. 10,449
  2. Avatar for Beta Folders 2. Beta Folders 79 pts. 10,413
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 61 pts. 10,380
  4. Avatar for Gargleblasters 4. Gargleblasters 47 pts. 10,332
  5. Avatar for Contenders 5. Contenders 35 pts. 10,287
  6. Avatar for Void Crushers 6. Void Crushers 26 pts. 10,273
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 19 pts. 10,225
  8. Avatar for GUGITBIOTECH 8. GUGITBIOTECH 14 pts. 9,515
  9. Avatar for Kotocycle 9. Kotocycle 10 pts. 9,271
  10. Avatar for Italiani Al Lavoro 10. Italiani Al Lavoro 7 pts. 9,081
  1. Avatar for dcrwheeler 11. dcrwheeler Lv 1 70 pts. 10,280
  2. Avatar for caglar 12. caglar Lv 1 68 pts. 10,280
  3. Avatar for Bruno Kestemont 13. Bruno Kestemont Lv 1 65 pts. 10,276
  4. Avatar for kabubi 14. kabubi Lv 1 63 pts. 10,273
  5. Avatar for eusair 15. eusair Lv 1 60 pts. 10,273
  6. Avatar for frood66 16. frood66 Lv 1 58 pts. 10,248
  7. Avatar for Susume 17. Susume Lv 1 56 pts. 10,237
  8. Avatar for Museka 18. Museka Lv 1 54 pts. 10,225
  9. Avatar for Glen B 19. Glen B Lv 1 52 pts. 10,182
  10. Avatar for Timo van der Laan 20. Timo van der Laan Lv 1 50 pts. 10,181

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 75. Players may use up to 90 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."