Placeholder image of a protein
Icon representing a puzzle

1378b: Hemagglutinin Binder Design: Loop Graft

Closed since almost 9 years ago

Advanced Overall Design

Summary

Created
May 16, 2017
Expires
Max points
100
Description

Note: This puzzle replaces Puzzle 1378, which was incorrectly calibrated for scoring. Players may load in solutions from Puzzle 1378.



Design a protein that contains the provided hemagglutinin-binding loop! Hemagglutinin is a protein from the influenza virus. It is displayed on the surface of the virus capsid, and allows the virus to recognize and infiltrate human cells. One particular region of the hemagglutinin protein undergoes a dramatic shift during infection; it's thought that stabilizing this region (e.g. with a protein binder) can prevent the normal function of hemagglutinin and stop infection. In fact, during an influenza infection, the immune system can sometimes raise antibody proteins that bind this portion of hemagglutinin to defend against further infection. In this puzzle, we've provided a portion of the hemagglutinin protein, as well as a hemagglutinin-binding loop that is derived from one such antibody protein. We're asking Foldit players to design a new protein that incorporates this same loop!



The backbone and certain residues of the loop are fixed, and the loop is held in place with strong constraints. The starting structure of the design has 53 residues, but players may add residues up to a total of 63. Players may also delete and redistribute residues on either side of the prescribed binding loop. See the puzzle comments for filter details.

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 11,113
  2. Avatar for Contenders 2. Contenders 76 pts. 10,649
  3. Avatar for Beta Folders 3. Beta Folders 56 pts. 10,598
  4. Avatar for Go Science 4. Go Science 41 pts. 10,583
  5. Avatar for Void Crushers 5. Void Crushers 29 pts. 10,480
  6. Avatar for HMT heritage 6. HMT heritage 20 pts. 10,388
  7. Avatar for Deleted group 7. Deleted group pts. 10,104
  8. Avatar for Gargleblasters 8. Gargleblasters 9 pts. 10,097
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 6 pts. 10,065
  10. Avatar for Natural Abilities 10. Natural Abilities 4 pts. 9,944
  1. Avatar for markm457
    1. markm457 Lv 1
    100 pts. 11,103
  2. Avatar for eusair 2. eusair Lv 1 97 pts. 10,867
  3. Avatar for johnmitch 3. johnmitch Lv 1 94 pts. 10,804
  4. Avatar for tokens 4. tokens Lv 1 91 pts. 10,694
  5. Avatar for Bletchley Park 5. Bletchley Park Lv 1 88 pts. 10,572
  6. Avatar for alcor29 6. alcor29 Lv 1 85 pts. 10,568
  7. Avatar for hpaege 7. hpaege Lv 1 82 pts. 10,546
  8. Avatar for LociOiling 8. LociOiling Lv 1 79 pts. 10,519
  9. Avatar for Timo van der Laan 9. Timo van der Laan Lv 1 77 pts. 10,480
  10. Avatar for retiredmichael 10. retiredmichael Lv 1 74 pts. 10,470

Comments

Mike Cassidy Lv 1

I can not run and rebuild or reset scripts; I can not reset manually; I can rebuild manually though if I convert it to loop I can not manually rebuild. Also Idealize scripts seem to do nothing; though again I can manually Idealize.

On MAC.