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1380: Large Monomer Design

Closed since almost 9 years ago

Intermediate Overall Design

Summary


Created
May 20, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for Team South Africa 12. Team South Africa 1 pt. 7,846
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  3. Avatar for freefolder 15. freefolder 1 pt. 7,145
  4. Avatar for DSN @ Home 16. DSN @ Home 1 pt. 6,537
  5. Avatar for Natural Abilities 17. Natural Abilities 1 pt. 4,297
  6. Avatar for Window Group 18. Window Group 1 pt. 1,345

  1. Avatar for LociOiling
    1. LociOiling Lv 1
    100 pts. 10,727
  2. Avatar for tokens 2. tokens Lv 1 97 pts. 10,645
  3. Avatar for reefyrob 3. reefyrob Lv 1 93 pts. 10,637
  4. Avatar for actiasluna 4. actiasluna Lv 1 89 pts. 10,623
  5. Avatar for hpaege 5. hpaege Lv 1 86 pts. 10,602
  6. Avatar for dcrwheeler 6. dcrwheeler Lv 1 82 pts. 10,598
  7. Avatar for markm457 7. markm457 Lv 1 79 pts. 10,594
  8. Avatar for bertro 8. bertro Lv 1 76 pts. 10,585
  9. Avatar for eusair 9. eusair Lv 1 73 pts. 10,576
  10. Avatar for Galaxie 10. Galaxie Lv 1 70 pts. 10,570

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85. Players may use up to 105 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."