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1380: Large Monomer Design

Closed since almost 9 years ago

Intermediate Overall Design

Summary


Created
May 20, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. The starting structure has 85 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for Beta Folders 100 pts. 10,727
  2. Avatar for Anthropic Dreams 2. Anthropic Dreams 76 pts. 10,645
  3. Avatar for Gargleblasters 3. Gargleblasters 56 pts. 10,623
  4. Avatar for Contenders 4. Contenders 41 pts. 10,578
  5. Avatar for Go Science 5. Go Science 29 pts. 10,496
  6. Avatar for Void Crushers 6. Void Crushers 20 pts. 10,471
  7. Avatar for L'Alliance Francophone 7. L'Alliance Francophone 14 pts. 10,378
  8. Avatar for Deleted group 8. Deleted group pts. 9,844
  9. Avatar for Italiani Al Lavoro 9. Italiani Al Lavoro 6 pts. 9,321
  10. Avatar for Russian team 10. Russian team 4 pts. 9,265

  1. Avatar for DScott 91. DScott Lv 1 1 pt. 6,959
  2. Avatar for bez.cerny 92. bez.cerny Lv 1 1 pt. 6,943
  3. Avatar for rezaefar 93. rezaefar Lv 1 1 pt. 6,915
  4. Avatar for me3253 94. me3253 Lv 1 1 pt. 6,824
  5. Avatar for pandapharmd 95. pandapharmd Lv 1 1 pt. 6,705
  6. Avatar for Jim Fraser 96. Jim Fraser Lv 1 1 pt. 6,686
  7. Avatar for aspadistra 97. aspadistra Lv 1 1 pt. 6,537
  8. Avatar for dbuske 98. dbuske Lv 1 1 pt. 6,518
  9. Avatar for Deleted player 99. Deleted player pts. 5,741
  10. Avatar for Deleted player 100. Deleted player pts. 5,512

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85. Players may use up to 105 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."