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1383: Medium Monomer Design

Closed since almost 9 years ago

Intermediate Overall Design

Summary


Created
May 24, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


  1. Avatar for freefolder 12. freefolder 1 pt. 7,829
  2. Avatar for Natural Abilities 13. Natural Abilities 1 pt. 4,892
  3. Avatar for DSN @ Home 14. DSN @ Home 1 pt. 3,832
  4. Avatar for xkcd 15. xkcd 1 pt. 0
  5. Avatar for SETI.Germany 16. SETI.Germany 1 pt. 0
  6. Avatar for Deleted group 17. Deleted group pts. 0

  1. Avatar for David M. 91. David M. Lv 1 1 pt. 7,740
  2. Avatar for Alistair69 92. Alistair69 Lv 1 1 pt. 7,694
  3. Avatar for FadingMist 93. FadingMist Lv 1 1 pt. 7,664
  4. Avatar for fritzbone 94. fritzbone Lv 1 1 pt. 7,653
  5. Avatar for larry25427 95. larry25427 Lv 1 1 pt. 7,530
  6. Avatar for MadCat08 96. MadCat08 Lv 1 1 pt. 7,492
  7. Avatar for fpc 97. fpc Lv 1 1 pt. 7,266
  8. Avatar for lange 98. lange Lv 1 1 pt. 7,204
  9. Avatar for jybourque 99. jybourque Lv 1 1 pt. 7,103
  10. Avatar for MichelleRna 100. MichelleRna Lv 1 1 pt. 7,066

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 75. Players may use up to 90 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."