Foldit

1383: Medium Monomer Design

Closed since almost 9 years ago

Summary

Created: May 24, 2017
Expires: June 02, 2017 at 23:00 UTC
Max points: 100

Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

11. Richard Dawkins Foundation 1 pt. 8,075
12. freefolder 1 pt. 7,829
13. Natural Abilities 1 pt. 4,892
14. DSN @ Home 1 pt. 3,832
15. xkcd 1 pt. 0
16. SETI.Germany 1 pt. 0
17. Deleted group pts. 0

11. Timo van der Laan Lv 1 68 pts. 10,362
12. Susume Lv 1 65 pts. 10,361
13. bertro Lv 1 62 pts. 10,361
14. retiredmichael Lv 1 60 pts. 10,359
15. anthion Lv 1 57 pts. 10,328
16. eusair Lv 1 55 pts. 10,321
17. hpaege Lv 1 53 pts. 10,318
18. Bletchley Park Lv 1 50 pts. 10,311
19. MurloW Lv 1 48 pts. 10,309
20. gitwut Lv 1 46 pts. 10,299

Comments

bkoep Staff Lv 1

May 24, 2017

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 75. Players may use up to 90 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."