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1386: Extra Large Monomer Design

Closed since almost 9 years ago

Intermediate Overall Design

Summary


Created
June 02, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. The starting structure has 95 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups


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  4. Avatar for Soggy Doglog 104. Soggy Doglog Lv 1 1 pt. 4,785
  5. Avatar for Mydogisa Toelicker 105. Mydogisa Toelicker Lv 1 1 pt. 4,486
  6. Avatar for Flagg65a 106. Flagg65a Lv 1 1 pt. 4,165
  7. Avatar for DipsyDoodle2016 107. DipsyDoodle2016 Lv 1 1 pt. 3,766
  8. Avatar for dbuske 108. dbuske Lv 1 1 pt. 3,096
  9. Avatar for lovro126 109. lovro126 Lv 1 1 pt. 477
  10. Avatar for 01010011111 110. 01010011111 Lv 1 1 pt. 0

Comments


bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 95. Players may use up to 120 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."