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1395: Medium Monomer Design: Smaller Core

Closed since almost 9 years ago

Intermediate Overall Design

Summary

Created
June 23, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The Core Existence filter has been relaxed such that only 25% of residues need to be buried in the protein core. The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Natural Abilities 11. Natural Abilities 1 pt. 7,594
  2. Avatar for HMT heritage 12. HMT heritage 1 pt. 3,884
  3. Avatar for Window Group 13. Window Group 1 pt. 2,565
  4. Avatar for Russian team 14. Russian team 1 pt. 1,515
  5. Avatar for DSN @ Home 15. DSN @ Home 1 pt. 0
  1. Avatar for smilingone 51. smilingone Lv 1 8 pts. 9,558
  2. Avatar for fishercat 52. fishercat Lv 1 7 pts. 9,511
  3. Avatar for Blipperman 53. Blipperman Lv 1 7 pts. 9,466
  4. Avatar for carsonfb 54. carsonfb Lv 1 6 pts. 9,419
  5. Avatar for Vincenzo Brancaccio 55. Vincenzo Brancaccio Lv 1 6 pts. 9,368
  6. Avatar for rabamino12358 56. rabamino12358 Lv 1 5 pts. 9,268
  7. Avatar for NinjaGreg 57. NinjaGreg Lv 1 5 pts. 9,259
  8. Avatar for FractalCuber 58. FractalCuber Lv 1 5 pts. 9,231
  9. Avatar for ProHarTius 59. ProHarTius Lv 1 4 pts. 9,218
  10. Avatar for mitarcher 60. mitarcher Lv 1 4 pts. 9,165

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 75. Players may use up to 90 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."