Placeholder image of a protein
Icon representing a puzzle

1395: Medium Monomer Design: Smaller Core

Closed since over 8 years ago

Intermediate Overall Design

Summary

Created
June 23, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 75-90 residues. The Core Existence filter has been relaxed such that only 25% of residues need to be buried in the protein core. The starting structure has 75 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Anthropic Dreams
    1. Anthropic Dreams
    100 pts. 10,540
  2. Avatar for Beta Folders 2. Beta Folders 70 pts. 10,486
  3. Avatar for Go Science 3. Go Science 47 pts. 10,426
  4. Avatar for Gargleblasters 4. Gargleblasters 30 pts. 10,380
  5. Avatar for Marvin's bunch 5. Marvin's bunch 19 pts. 10,308
  6. Avatar for Contenders 6. Contenders 11 pts. 10,299
  7. Avatar for Void Crushers 7. Void Crushers 7 pts. 10,246
  8. Avatar for L'Alliance Francophone 8. L'Alliance Francophone 4 pts. 10,228
  9. Avatar for Italiani Al Lavoro 9. Italiani Al Lavoro 2 pts. 8,812
  10. Avatar for Deleted group 10. Deleted group pts. 7,673
  1. Avatar for jamiexq 31. jamiexq Lv 1 25 pts. 10,069
  2. Avatar for Bautho 32. Bautho Lv 1 24 pts. 10,053
  3. Avatar for mimi 33. mimi Lv 1 22 pts. 10,000
  4. Avatar for Bletchley Park 34. Bletchley Park Lv 1 21 pts. 9,997
  5. Avatar for Deleted player 35. Deleted player pts. 9,992
  6. Avatar for uihcv 36. uihcv Lv 1 19 pts. 9,931
  7. Avatar for weitzen 37. weitzen Lv 1 18 pts. 9,931
  8. Avatar for pvc78 38. pvc78 Lv 1 17 pts. 9,901
  9. Avatar for Mike Cassidy 39. Mike Cassidy Lv 1 16 pts. 9,885
  10. Avatar for dssb 40. dssb Lv 1 15 pts. 9,880

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 25% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 75. Players may use up to 90 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."