1412: Sketchbook Puzzle: Unsolved Denovo Freestyle 105

Closed since over 8 years ago

Summary

• Created: August 02, 2017
• Expires: August 09, 2017 at 23:00 UTC
• Max points: 100

Description

Focus on your early game as we revisit puzzle 1381: Unsolved De-novo Freestyle 105. In this Sketchbook puzzle, you have 250 moves at your disposal. Once you use them up, you can reset and try something else!

TELEKHREELKEFLKKEGITNVEIRIDNGRLEVRVEGGTERLKRFLEELRQKLEKKGYTVDIKIE

Top groups

• 1. Anthropic Dreams 100 pts. 9,474
• 2. Gargleblasters 76 pts. 9,435
• 3. Beta Folders 56 pts. 9,420
• 4. Void Crushers 41 pts. 9,290
• 5. Marvin's bunch 29 pts. 9,282
• 6. Go Science 20 pts. 9,270
• 7. Deleted group pts. 9,160
• 8. Contenders 9 pts. 9,104
• 9. Russian team 6 pts. 8,969
• 10. L'Alliance Francophone 4 pts. 8,903

Top evolvers

• 1. Galaxie 100 pts. 9,474
• 2. phi16 83 pts. 9,460
• 3. gmn 68 pts. 9,457
• 4. jamiexq 55 pts. 9,455
• 5. alwen 44 pts. 9,452
• 6. LociOiling 35 pts. 9,420
• 7. reefyrob 27 pts. 9,411
• 8. alcor29 21 pts. 9,387
• 9. lamoille 16 pts. 9,335
• 10. retiredmichael 12 pts. 9,326

Comments

[Susume]

There is a picture of the protein in the blog for all to see - scroll down to the one from Waya, Galaxie, Susume from puzzle 1297.

[Aubade01]

Puzzle appears to be a design not De-novo.

"1297: 65 Residue Monomer Design: No Rebuilding!"

Blog picture 1297 has only a single coil not the two in Sketchbook.

I was thinking more along the lines of a picture link embedded in the puzzle description. We should be encouraging new players and not expect them to know everything veterans know.

Aubade00 / 01

[LociOiling]

The protein in this puzzle is the first Foldit player design to be grown, crystallized, and solved by X-ray diffraction.

As Susume mentions, the protein was created in puzzle 1297. After the wet lab, it was presented as a de-novo in puzzle 1381, and an electron density in puzzle 1384.

See Design Puzzle Results on the wiki, which includes a nice image posted by Waya for 1297. The Puzzle 1381 gallery shows the protein from two angles.

I'm still not convinced about the sketchbook format, but we've had lots of practice with this particular protein already. I'm sure it will end up the PDB someday soon.

[Bruno Kestemont]

For us, "early game" (hand fold and "observing" the protein) is the most (human) time consuming. This is also our most valuable contribution for this project. Overnight scripts or "moves" are almost "for free" (concerning Human resources). So the question is not the number of moves but to encourage us to spend more "hand fold" time.

Suggestion (just brain storming)

Game in 2 (3) rounds:
1-one round pure hand fold and no score (no rank, no points, no scripts unless GUI, no share)
2-one almost normal round with possibility to load solutions from round 1 in different identified unique tracks- At the end of this round, the score is not immediately calculated according to the apparent top solution's rank BUT …
3-A definitive score and ranking "round" where the player's score and rank is the sum of the 2 current best separate original solutions (at an unique separate paths starting in round 1 ending round 2).

In round 1, my strategy would be to try as many and diverse manual designs as possible, regardless of scores.

In round 2, I'll develop the full potential of several of them in order to also find the second best one.

I use the "decreasing return" property of the puzzles. If I see that my best solution is near to its mojo (gaining few points a day), I'll be encouraged to concentrate on second best solutions with higher "points a day" potential, in order to maximize the sum of my 2 best separate solutions.

Not sure it works. Just thinking.