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1424: Extra Large Monomer Design

Closed since over 8 years ago

Intermediate Overall Design

Summary

Created
September 01, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. We've adjusted the scoring function here so that alanine residues are more tolerable in loops (they are still restricted in helices and sheets!). The starting structure has 95 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

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  4. Avatar for DSN @ Home 14. DSN @ Home 1 pt. 385
  5. Avatar for xkcd 15. xkcd 1 pt. 0
  1. Avatar for eromana
    1. eromana Lv 1
    100 pts. 11,040
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  3. Avatar for andrewxc 3. andrewxc Lv 1 66 pts. 11,035
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  5. Avatar for Enzyme 5. Enzyme Lv 1 42 pts. 11,033
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  7. Avatar for LociOiling 7. LociOiling Lv 1 26 pts. 10,991
  8. Avatar for bertro 8. bertro Lv 1 20 pts. 10,989
  9. Avatar for reefyrob 9. reefyrob Lv 1 15 pts. 10,987
  10. Avatar for retiredmichael 10. retiredmichael Lv 1 11 pts. 10,979

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