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1424: Extra Large Monomer Design

Closed since over 8 years ago

Intermediate Overall Design

Summary

Created
September 01, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. We've adjusted the scoring function here so that alanine residues are more tolerable in loops (they are still restricted in helices and sheets!). The starting structure has 95 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for CureCoin 11. CureCoin 1 pt. 6,596
  2. Avatar for Natural Abilities 12. Natural Abilities 1 pt. 3,775
  3. Avatar for St Pat's Biology 203 13. St Pat's Biology 203 1 pt. 469
  4. Avatar for DSN @ Home 14. DSN @ Home 1 pt. 385
  5. Avatar for xkcd 15. xkcd 1 pt. 0
  1. Avatar for isaksson 11. isaksson Lv 1 68 pts. 10,758
  2. Avatar for fiendish_ghoul 12. fiendish_ghoul Lv 1 65 pts. 10,742
  3. Avatar for dcrwheeler 13. dcrwheeler Lv 1 62 pts. 10,730
  4. Avatar for Vinara 14. Vinara Lv 1 60 pts. 10,664
  5. Avatar for stomjoh 15. stomjoh Lv 1 57 pts. 10,663
  6. Avatar for Skippysk8s 16. Skippysk8s Lv 1 55 pts. 10,644
  7. Avatar for caglar 17. caglar Lv 1 52 pts. 10,612
  8. Avatar for Glen B 18. Glen B Lv 1 50 pts. 10,601
  9. Avatar for hpaege 19. hpaege Lv 1 48 pts. 10,572
  10. Avatar for Timo van der Laan 20. Timo van der Laan Lv 1 46 pts. 10,570

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