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1424: Extra Large Monomer Design

Closed since over 8 years ago

Intermediate Overall Design

Summary

Created
September 01, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 95-120 residues. We've adjusted the scoring function here so that alanine residues are more tolerable in loops (they are still restricted in helices and sheets!). The starting structure has 95 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for CureCoin 11. CureCoin 1 pt. 6,596
  2. Avatar for Natural Abilities 12. Natural Abilities 1 pt. 3,775
  3. Avatar for St Pat's Biology 203 13. St Pat's Biology 203 1 pt. 469
  4. Avatar for DSN @ Home 14. DSN @ Home 1 pt. 385
  5. Avatar for xkcd 15. xkcd 1 pt. 0
  1. Avatar for rabamino12358 61. rabamino12358 Lv 1 5 pts. 8,280
  2. Avatar for Auntecedent 62. Auntecedent Lv 1 5 pts. 8,278
  3. Avatar for Kingpudding 63. Kingpudding Lv 1 4 pts. 8,158
  4. Avatar for weitzen 64. weitzen Lv 1 4 pts. 7,917
  5. Avatar for mitarcher 65. mitarcher Lv 1 4 pts. 7,901
  6. Avatar for taminnugget 66. taminnugget Lv 1 4 pts. 7,899
  7. Avatar for Arne Heessels 67. Arne Heessels Lv 1 3 pts. 7,706
  8. Avatar for kinnom 68. kinnom Lv 1 3 pts. 7,545
  9. Avatar for xabxs 69. xabxs Lv 1 3 pts. 7,536
  10. Avatar for tomespen 70. tomespen Lv 1 3 pts. 7,508

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