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1430: Large Monomer Design

Closed since over 8 years ago

Intermediate Overall Design

Summary

Created
September 15, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 85 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 10,688
  2. Avatar for Gargleblasters 2. Gargleblasters 70 pts. 10,670
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 47 pts. 10,594
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  10. Avatar for :) 10. :) 1 pt. 9,011
  1. Avatar for e987 91. e987 Lv 1 1 pt. 7,025
  2. Avatar for hardwood198 92. hardwood198 Lv 1 1 pt. 6,976
  3. Avatar for spiveyds 93. spiveyds Lv 1 1 pt. 5,867
  4. Avatar for Soggy Doglog 94. Soggy Doglog Lv 1 1 pt. 5,061
  5. Avatar for Festering Wounds 95. Festering Wounds Lv 1 1 pt. 5,061
  6. Avatar for Mydogisa Toelicker 96. Mydogisa Toelicker Lv 1 1 pt. 5,060
  7. Avatar for Mohambone 97. Mohambone Lv 1 1 pt. 5,036
  8. Avatar for Fog Darts 98. Fog Darts Lv 1 1 pt. 5,018
  9. Avatar for lamoille 99. lamoille Lv 1 1 pt. 4,394
  10. Avatar for claudine.carol 100. claudine.carol Lv 1 1 pt. 2,463

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85. Players may use up to 105 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."