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1430: Large Monomer Design

Closed since over 8 years ago

Intermediate Overall Design

Summary

Created
September 15, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 85-105 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 85 residues, but more can be added at a cost of 23 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Beta Folders
    1. Beta Folders
    100 pts. 10,688
  2. Avatar for Gargleblasters 2. Gargleblasters 70 pts. 10,670
  3. Avatar for Anthropic Dreams 3. Anthropic Dreams 47 pts. 10,594
  4. Avatar for Go Science 4. Go Science 30 pts. 10,561
  5. Avatar for Contenders 5. Contenders 19 pts. 10,548
  6. Avatar for Void Crushers 6. Void Crushers 11 pts. 10,447
  7. Avatar for Marvin's bunch 7. Marvin's bunch 7 pts. 10,421
  8. Avatar for Deleted group 8. Deleted group pts. 9,958
  9. Avatar for L'Alliance Francophone 9. L'Alliance Francophone 2 pts. 9,313
  10. Avatar for :) 10. :) 1 pt. 9,011
  1. Avatar for alcor29 31. alcor29 Lv 1 27 pts. 9,860
  2. Avatar for toshiue 32. toshiue Lv 1 26 pts. 9,853
  3. Avatar for Bautho 33. Bautho Lv 1 25 pts. 9,831
  4. Avatar for fishercat 34. fishercat Lv 1 24 pts. 9,798
  5. Avatar for Mike Cassidy 35. Mike Cassidy Lv 1 22 pts. 9,719
  6. Avatar for georg137 36. georg137 Lv 1 21 pts. 9,670
  7. Avatar for ViJay7019 37. ViJay7019 Lv 1 20 pts. 9,634
  8. Avatar for DoctorSockrates 38. DoctorSockrates Lv 1 19 pts. 9,595
  9. Avatar for weitzen 39. weitzen Lv 1 18 pts. 9,587
  10. Avatar for hansvandenhof 40. hansvandenhof Lv 1 17 pts. 9,399

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 35% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 85. Players may use up to 105 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."