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1437: Small Monomer Design

Closed since over 8 years ago

Intermediate Overall Design

Summary

Created
October 06, 2017
Expires
Max points
100
Description

This puzzle challenges players to design a single-chain protein with 65-75 residues. We've softened the penalties associated with the Core Existence filter, which have typically been very steep. The starting structure has 65 residues, but more can be added at a cost of 16 points per residue. See the puzzle comments for filter details. The Baker Lab will run folding predictions on your solutions for this puzzle, and those that perform well will be synthesized in the lab. Remember, you can use the Upload for Scientists button for up to 5 designs that you want us to look at, even if they are not the best-scoring solutions!

Top groups

  1. Avatar for Rice Biochemistry 21. Rice Biochemistry 1 pt. 0
  1. Avatar for marlasanchez 131. marlasanchez Lv 1 1 pt. 3,710
  2. Avatar for kristian55 132. kristian55 Lv 1 1 pt. 3,685
  3. Avatar for aanalla 133. aanalla Lv 1 1 pt. 3,684
  4. Avatar for abledbody 134. abledbody Lv 1 1 pt. 0
  5. Avatar for mayday123 135. mayday123 Lv 1 1 pt. 0
  6. Avatar for 01010011111 136. 01010011111 Lv 1 1 pt. 0
  7. Avatar for PBanks2017 137. PBanks2017 Lv 1 1 pt. 0
  8. Avatar for O Seki To 138. O Seki To Lv 1 1 pt. 0
  9. Avatar for multaq 139. multaq Lv 1 1 pt. 0
  10. Avatar for biochem123 140. biochem123 Lv 1 1 pt. 0

Comments

bkoep Staff Lv 1

Residue IE Score: Monitors that all PHE, TYR, and TRP residues are scoring well.

Core Existence: Ensures that at least 30% of the residues are buried in the core of your design.

Secondary Structure: Checks that no more than 50% of residues are in helices; penalties are incurred if more than 50% of residues form helices.

Secondary Structure Design: Penalizes all CYS residues. Penalizes GLY, ALA residues in sheets; penalizes GLY, ALA, SER, THR in helices.

Residue Count: Penalizes extra residues inserted beyond the starting 65. Players may use up to 75 residues in total.

Ideal Loops: Penalizes loops that do not conform to preferred ABEGO patterns. Use Auto Structures to see which residues count as "loops."